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Movies Like The Strange Case of Doctor Rx

If you liked The Strange Case of Doctor Rx (1942), a horror and mystery movie directed by William Nigh, here are 20 movies with a similar feel, based on TMDB's recommendations. Each one links to its cast, trailer and where it's streaming.

  1. 1Tightrope

    Tightrope (1984)

    ★ 6.2/10Also mystery

    Wes Block is a detective who's put on the case of a serial killer whose victims are young and pretty women. The murders are getting personal when the killer chooses victims who are acquaintances of Block. Even his…

  2. 2The Mirror Crack'd

    The Mirror Crack'd (1980)

    ★ 6.1/10Also mystery

    Jane Marple solves the mystery when a local woman is poisoned and a visiting movie star seems to have been the intended victim.

  3. 3Cult Killer

    Cult Killer (2024)

    ★ 6.4/10Also mystery and horror

    A private investigator is forced into a dangerous alliance with a killer in order to uncover a quiet town’s grisly criminal underbelly and clear the name of her mentor, who is implicated in the crimes.

  4. 4Crooked House

    Crooked House (2017)

    ★ 6.4/10Also mystery

    A private investigator helps a former flame solve the murder of her wealthy grandfather, who lived in a sprawling estate surrounded by his idiosyncratic family.

  5. 5I See You

    I See You (2019)

    ★ 7/10Also horror and mystery

    When a 12-year-old boy goes missing at a local park, a detective investigates the case to help the boy's family find answers.

  6. 6Strange Harvest

    Strange Harvest (2025)

    ★ 6.6/10Also horror and mystery

    Detectives are thrust into a chilling hunt for a sadistic serial killer from the past whose return marks the beginning of a new wave of grotesque, otherworldly crimes tied to a cosmic force.

  7. 7Lady in the Lake

    Lady in the Lake (1946)

    ★ 6.1/10Also mystery

    Private eye Phillip Marlowe wants to get out of the detective racket and into crime writing. But when he's called to the office of editor Adrienne Fromsett, it's not to talk about his story ideas — she wants him to…

  8. 8Striking Distance

    Striking Distance (1993)

    ★ 5.9/10Also mystery

    Demoted Pittsburgh cop Tom Hardy works river patrol while a serial killer targets women from his past, forcing him to conduct an unauthorized investigation to prove his innocence and expose a dirty cop.

  9. 9The Maltese Falcon

    The Maltese Falcon (1941)

    ★ 7.7/10Also mystery

    A private detective takes on a case that involves him with three eccentric criminals, a beautiful liar, and their quest for a priceless statuette.

  10. 10The Big Sleep

    The Big Sleep (1946)

    ★ 7.6/10Also mystery

    Private Investigator Philip Marlowe is hired by wealthy General Sternwood regarding a matter involving his youngest daughter Carmen. Before the complex case is over, Marlowe sees murder, blackmail, deception, and what…

  11. 11Cleaner

    Cleaner (2007)

    ★ 6.1/10Also mystery

    Single father and former cop Tom Cutler has an unusual occupation: he cleans up death scenes. But when he's called in to sterilize a wealthy suburban residence after a brutal shooting, Cutler is shocked to learn he may…

  12. 12Body Cam

    Body Cam (2020)

    ★ 6.2/10Also horror and mystery

    As a police officer investigates the gruesome murder of her colleague, she discovers that a mysterious supernatural force is behind it.

  13. 13Muzzle: City of Wolves

    Muzzle: City of Wolves (2025)

    ★ 6.6/10Also mystery

    LAPD officer Jake Rosser endeavors to lead a peaceful life with his family and retired K-9 officer, Socks. However, tranquility dissolves into chaos when a gang targets them in a brutal attack. Alongside his new K-9…

  14. 14The Seven-Ups

    The Seven-Ups (1973)

    ★ 6.3/10Also mystery

    A tough detective who is part of an elite New York City unit is trying to find out who killed his partner, but uncovers a plot to kidnap mobsters for money.

  15. 15Woman on the Run

    Woman on the Run (1950)

    ★ 6.8/10Also mystery

    Frank Johnson, a sole witness to a gangland murder, goes into hiding and is trailed by Police Inspector Ferris, on the theory that Frank is trying to escape from possible retaliation. Frank's wife, Eleanor, suspects he…

  16. 16The Adventures of Sherlock Holmes

    The Adventures of Sherlock Holmes (1939)

    ★ 6.9/10Also mystery

    Having once again avoided criminal conviction, Professor Moriarity develops a murderous plan to “finish off” his last major nemesis, Sherlock Holmes, by making him fail to prevent the perfect crime. Does it involve a…

  17. 17Shadow of a Doubt

    Shadow of a Doubt (1943)

    ★ 7.5/10Also mystery

    In sleepy Santa Rosa, restless young Charlie’s world brightens when her sophisticated Uncle Charlie arrives for a long visit. But as his behavior grows increasingly strange, she begins to suspect that her beloved uncle…

  18. 18Psycho Killer

    Psycho Killer (2026)

    ★ 6.7/10Also horror and mystery

    Following the brutal murder of her husband, a Kansas highway patrol officer sets out on a journey to track down the perpetrator. As the hunt progresses, she comes to realize the man responsible is a sadistic serial…

  19. 19God Told Me To

    God Told Me To (1976)

    ★ 5.9/10Also horror and mystery

    A New York detective investigates a series of murders committed by random citizens who claim that 'God told them to'.

  20. 20Blue Velvet

    Blue Velvet (1986)

    ★ 7.6/10Also mystery

    The discovery of a severed human ear found in a field leads a young man on an investigation related to a beautiful, mysterious nightclub singer and a group of psychopathic criminals who have kidnapped her child.

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