Movies Like Designer Genes

If you liked Designer Genes (1990), a movie directed by Paul Thomas, here are 20 movies with a similar feel, based on TMDB's recommendations. Each one links to its cast, trailer and where it's streaming.

1
The Back-Up Plan (2010)
★ 6.1/10
When Zoe tires of looking for Mr. Right, she decides to have a baby on her own. But on the day she's artificially inseminated, she meets Stan, who seems to be just who she's been searching for all her life. Now, Zoe…
2
Road Trip (2000)
★ 6.3/10
After a student at the University of Ithaca films his one-night stand with a beautiful sorority girl, he discovers one of his friends has accidentally mailed the homemade sex tape to his girlfriend in Austin. In a…
3
Dying Young (1991)
★ 6.7/10
After she discovers that her boyfriend has betrayed her, Hilary O'Neil is looking for a new start and a new job. She begins to work as a private nurse for a young man suffering from blood cancer. Slowly, they fall in…
4
Everything You Always Wanted to Know About Sex *But Were Afraid to Ask (1972)
★ 6.5/10
A collection of seven vignettes, which each address a question concerning human sexuality. From aphrodisiacs to sexual perversion to the mystery of the male orgasm, characters like a court jester, a doctor, a queen and…
5
Better Living Through Chemistry (2014)
★ 5.9/10
A straight-laced pharmacist's uneventful life spirals out of control when he starts an affair with a trophy wife customer who takes him on a joyride involving sex, drugs and possibly murder.
6
Ted 2 (2015)
★ 6.3/10
Newlywed couple Ted and Tami-Lynn want to have a baby, but in order to qualify to be a parent, Ted will have to prove he's a person in a court of law.
7
Pain Hustlers (2023)
★ 6.6/10
After losing her job, a single mom falls into a lucrative but ultimately dangerous scheme selling prescription drugs.
8
Good Luck Chuck (2007)
★ 5.9/10
Cursed since childhood, dentist Charlie Logan cannot find the right woman. Even worse, he learns that each of his ex-girlfriends finds true love with the man she meets after her relationship with him ends. Hearing of…
9
Thin Ice (2012)
★ 6.5/10
A dishonest insurance salesman's life quickly disintegrates during a Wisconsin winter when he teams up with a psychopath to steal a rare violin at the home of a reclusive farmer.
10
Who's Minding the Store? (1963)
★ 6.8/10
Norman Phiffer, a proud man in a humble life, doesn't know that his girlfriend, Barbara, is heir to the Tuttle Department Store dynasty. Mrs. Tuttle, Barbara's mother, is determined to split the two lovers, and hires…
11
The Disorderly Orderly (1964)
★ 6.3/10
Poor Jerome Littlefield. He wants to be a doctor – but that's not exactly the perfect career choice when you're hopelessly squeamish. So he settles for the job of orderly at the Whitestone Sanitarium, a career move…
12
He's Just Not That Into You (2009)
★ 6.6/10
Remember that really cute girl/guy who said they'd call – and didn't? Maybe they lost your number. Maybe they're in the hospital. Maybe they're awed by your looks, brains or success. Or maybe... They're just not that…
13
One Flew Over the Cuckoo's Nest (1975)
★ 8.4/10
A petty criminal fakes insanity to serve his sentence in a mental ward rather than prison. He soon finds himself as a leader to the other patients—and an enemy to the cruel, domineering nurse who runs the ward.
14
Everything, Everything (2017)
★ 7.2/10
A teenager who's lived a sheltered life because she's allergic to everything, falls for the boy who moves in next door.
15
Monkey Business (1952)
★ 6.7/10
Research chemist Barnaby Fulton works on a fountain of youth pill for a chemical company. One of the labs chimps gets loose in the laboratory and mixes chemicals, but then pours the mix into the water cooler. When…
16
Delivery Man (2013)
★ 6.3/10
An affable underachiever finds out he's fathered 533 children through anonymous donations to a fertility clinic 20 years ago. Now he must decide whether or not to come forward when 142 of them file a lawsuit to reveal…
17
Dirty Sexy Saint (2019)
★ 6.3/10
Clay Kincaid hates the nickname 'Saint', he got for being too kind to stray animals and desperate people. Especially when it comes to women. With a rough and damaged past that has left him jaded, he doesn't do…
18
Dead Ringers (1988)
★ 7.1/10
Elliot, a successful gynecologist, works at the same practice as his identical twin, Beverly. Elliot is attracted to many of his patients and has affairs with them. When he inevitably loses interest, he will give the…
19
Comet (2014)
★ 6.6/10
When a chance encounter brings together the cynical Dell and the quick-witted Kimberly, the stage is set for a tempestuous love affair that unfolds like a puzzle. As the film zigzags back and forth in time — from a…
20
They Live by Night (1949)
★ 6.8/10
An escaped convict, injured during a robbery, falls in love with the woman who nurses him back to health, but their relationship seems doomed from the beginning.