Movies Like My Sister's Keeper

If you liked My Sister's Keeper (2002), a drama movie directed by Ron Lagomarsino, here are 20 movies with a similar feel, based on TMDB's recommendations. Each one links to its cast, trailer and where it's streaming.

1
The Glass House (2001)
★ 6/10Also drama
When Ruby and Rhett's parents are killed in a car accident, their carefree teenage lives are suddenly shattered. Moving to an incredible house in Malibu with the Glasses', old friends of the family, seems to be the…
2
Rachel Getting Married (2008)
★ 6.3/10Also drama
A young woman who has been in and out from rehab for the past 10 years returns home for the weekend for her sister's wedding.
3
Sister Cities (2016)
★ 6.4/10Also drama
Based on the internationally-acclaimed play by Colette Freedman, the story of 4 estranged sisters who reunite for their mother’s alleged suicide.
4
Father Mother Sister Brother (2025)
★ 6.4/10Also drama
Estranged siblings reunite after years apart, forced to confront unresolved tensions and reevaluate their strained relationships with their emotionally distant parents.
5
Marvin's Room (1996)
★ 6.7/10Also drama
A leukemia patient attempts to end a 20-year feud with her sister to get her bone marrow.
6
Brothers (2009)
★ 7.3/10Also drama
When his helicopter goes down during his fourth tour of duty in Afghanistan, Marine Sam Cahill is presumed dead. Back home, brother Tommy steps in to look over Sam’s wife, Grace, and two children. Sam’s surprise…
7
Love Streams (1984)
★ 7.2/10Also drama
Two closely-bound, emotionally wounded siblings reunite after years apart.
8
A Streetcar Named Desire (1951)
★ 7.6/10Also drama
A disturbed, aging Southern belle moves in with her sister for solace — but being face-to-face with her brutish brother-in-law accelerates her downward spiral.
9
The Skeleton Twins (2014)
★ 6.6/10Also drama
Estranged twins Maggie and Milo coincidentally cheat death on the same day, prompting them to reunite and confront the reasons their lives went so wrong. As the twins' reunion reinvigorates them, they realize the key…
10
What We Hide (2025)
★ 6.4/10Also drama
After their mother dies of an overdose, two sisters hide her body to avoid being separated by the foster system, but as their secret threatens to unravel, they must confront the consequences of their desperate choice.
11
Paris, Texas (1984)
★ 8.1/10Also drama
A man wanders out of the desert not knowing who he is. His brother finds him, and helps to pull his memory back of the life he led before he walked out on his family and disappeared four years earlier.
12
Is God Is (2026)
★ 5.9/10Also drama
Two sisters embark on an epic quest for revenge, confronting a charged family history that pushes them to extraordinary lengths.
13
Goodbye June (2025)
★ 6.5/10Also drama
Four siblings' lives change drastically when their ailing mother takes a turn for the worse over the holiday season.
14
You Can Count on Me (2000)
★ 6.9/10Also drama
A single mother's life is thrown into turmoil after her struggling, rarely-seen younger brother returns to town.
15
The Cement Garden (1993)
★ 6.8/10Also drama
After the death of her husband, the mother of Julie, Jack, Sue and Tom begins to suffer from a mysterious illness. Aware that she is going to have to go into hospital she opens a bank account for the children, so that…
16
LOLA (2023)
★ 6.4/10Also drama
Sussex, England, 1938. Shortly before the outbreak of World War II, Thomasina and Martha Hanbury, two ingenious sisters, create LOLA, a miraculous machine.
17
Into the Forest (2016)
★ 5.8/10Also drama
In the not too distant future, two young women who live in a remote ancient forest discover the world around them is on the brink of an apocalypse. Informed only by rumor, they fight intruders, disease, loneliness &…
18
Nell (1994)
★ 6.5/10Also drama
In a remote woodland cabin, a small town doctor discovers Nell — a beautiful young hermit woman with many secrets.
19
Blue Jasmine (2013)
★ 7/10Also drama
After experiencing a traumatic misfortune, Jasmine French, a wealthy woman from New York, moves to San Francisco to live with her foster sister Ginger and the firm purpose of getting a new life, but she will be haunted…
20
The Client (1994)
★ 6.7/10Also drama
A street-wise kid, Mark Sway, sees the suicide of Jerome Clifford, a prominent Louisiana lawyer, whose current client is Barry 'The Blade' Muldano, a Mafia hit-man. Before Jerome shoots himself, he tells Mark where the…