Movies Like Extinction: Patient Zero

If you liked Extinction: Patient Zero (2015), a thriller movie directed by Joe Eckardt, here are 20 movies with a similar feel, based on TMDB's recommendations. Each one links to its cast, trailer and where it's streaming.

1
Eradication (2022)
★ 6.1/10Also thriller
When an unknown disease wipes out most of the world’s population, a man with unique blood is isolated for study. Fearing for his wife’s safety, he breaks his quarantine – into a world overrun by monstrous Infected and…
2
Wardriver (2026)
★ 7.4/10Also thriller
He’s a Wardriver: a hacker who steals from banks, not people—until he’s noticed. Now the money turns violent, and the woman caught in it could save him or kill them both.
3
The Experiment (2010)
★ 6.4/10Also thriller
20 men are chosen to participate in the roles of guards and prisoners in a psychological study that ultimately spirals out of control.
4
Contagion (2011)
★ 6.7/10Also thriller
As an epidemic of a lethal airborne virus - that kills within days - rapidly grows, the worldwide medical community races to find a cure and control the panic that spreads faster than the virus itself.
5
Containment (2015)
★ 5.9/10Also thriller
Neighbors in a block wake one morning to find they have been sealed inside their apartments. Can they work together to find out why? Or will they destroy each other in their fight to escape?
6
Rogue Agent (2022)
★ 6.3/10Also thriller
Conman Robert Freegard poses as an undercover MI5 agent and kidnaps countless victims amidst a high-stakes manhunt, until the woman who fell for him brings him to justice.
7
Black Widow (1987)
★ 6.2/10Also thriller
Federal agent Alexandra Barnes believes that Catherine Petersen is a serial killer who marries rich men and then murders them for their money. But since Catherine is seemingly a master of disguise and has multiple…
8
Warning Sign (1985)
★ 6/10Also thriller
An accident occurs in an ultra-secret government biological weapons laboratory spreading a sinister bacteria.
9
Blackwood (2014)
★ 5.9/10Also thriller
Having recovered from a shattering emotional breakdown, college professor Ben Marshall relocates to the countryside with his wife and young son, hoping for a fresh start. He has a teaching job lined up and a new home…
10
Doomsday (2008)
★ 5.9/10Also thriller
The lethal Reaper virus spreads throughout Britain—infecting millions and killing hundreds of thousands. Authorities brutally and successfully quarantine the country but, three decades later, the virus resurfaces in a…
11
Songbird (2020)
★ 6.1/10Also thriller
During a pandemic lockdown, Nico, a young man with rare immunity, must overcome martial law, murderous vigilantes and a powerful family to reunite with his love, Sara.
12
Cheat (2023)
★ 7.1/10Also thriller
On the surface it's believed to be another urban legend - a supernatural being from the afterlife is violently killing anyone who cheats on their significant other in the small college town of Silvercreek…
13
Zip Wire (2026)
★ 7.4/10Also thriller
When her ground-breaking pharmaceutical discovery is stolen and partner murdered, researcher Amy must face her fear of heights to escape nefarious attackers, with the only path to salvation being a treacherous aerial…
14
Whisper (2007)
★ 6.3/10Also thriller
Sinister things begin happening to kidnappers who are holding a young boy for ransom in a remote cabin.
15
Right at Your Door (2006)
★ 5.8/10Also thriller
A dirty bomb goes off in Los Angeles, jamming freeways and spreading a toxic cloud.
16
Off the Grid (2025)
★ 6.4/10Also thriller
After a morally-bankrupt company tries to weaponize a brilliant scientist's revolutionary technology, he goes off the grid to safeguard humanity. When the company sends a strike force to find him, they make their…
17
All the Devils Are Here (2025)
★ 6.2/10Also thriller
After a heist, four criminals lay low in a remote safehouse, waiting for orders. As paranoia builds, one thing becomes clear — the real threat may not be outside, but among them.
18
You'll Never Find Me (2024)
★ 6.1/10Also thriller
Patrick, a strange and lonely resident, lives in a mobile home at the back of an isolated caravan park. After a violent thunderstorm erupts, a mysterious young woman appears at his door, seeking shelter from the…
19
Dangerous Game: The Legacy Murders (2022)
★ 6/10Also thriller
A family reunion at a remote mansion takes a lethal turn when they are trapped inside and forced to play a deadly survival game where only one will make it out alive.
20
Chief of Station (2024)
★ 6.3/10Also thriller
After learning that the death of his wife was not an accident, a former CIA Station Chief is forced back into the espionage underworld, teaming up with an adversary to unravel a conspiracy that challenges everything he…