Movies Like 50/50

If you liked 50/50 (2011), a comedy and drama movie directed by Jonathan Levine, here are 20 movies with a similar feel, based on TMDB's recommendations. Each one links to its cast, trailer and where it's streaming.

1
Paddleton (2019)
★ 7/10Also comedy and drama
An unlikely friendship between two neighbors becomes an unexpectedly emotional journey when the younger man is diagnosed with terminal cancer.
2
Funny People (2009)
★ 5.9/10Also comedy and drama
Famous and wealthy funnyman George Simmons doesn't give much thought to how he treats people until a doctor delivers stunning health news, forcing George to reevaluate his priorities with a little help from aspiring…
3
Wit (2001)
★ 7.3/10Also drama
A renowned professor is forced to reassess her life when she is diagnosed with terminal ovarian cancer.
4
Standing Up, Falling Down (2020)
★ 6.3/10Also comedy and drama
An unlikely friendship kindles between a struggling stand-up comedian from L.A. — forced to move back home to Eastern Long Island with his tail between his legs — and a tragically flawed, but charming and charismatic…
5
SubUrbia (1997)
★ 6.2/10Also comedy and drama
A group of suburban teenagers try to support each other through the difficult task of becoming adults.
6
Ghostlight (2024)
★ 7.2/10Also comedy and drama
When melancholic construction worker Dan finds himself drifting from his wife and daughter, he discovers community and purpose in a local theater's production of Romeo and Juliet. As the drama onstage starts to mirror…
7
House of D (2004)
★ 6.3/10Also comedy and drama
In the present, artist Tom Warshaw recalls his traumatic coming of age. As a 13-year-old growing up in New York City in 1973, Tom hangs out with Pappass, a mentally disabled man. With Tom's mother battling depression…
8
Henry Poole Is Here (2008)
★ 5.9/10Also comedy and drama
Henry Poole abandons his fiancée and family business to spend what he believes are his remaining days alone. The discovery of a 'miracle' by a nosy neighbor ruptures his solitude and restores his faith in life.
9
About Alex (2014)
★ 6.1/10Also comedy and drama
When a group of old college friends reunite over a long weekend after one of them attempts suicide, old crushes and resentments shine light on their life decisions, and ultimately push friendships and relationships to…
10
CQ (2001)
★ 5.9/10Also comedy and drama
A young filmmaker in 1960s Paris juggles directing a cheesy sci-fi debacle, directing his own personal art film, coping with his crumbling relationship with his girlfriend, and a new-found infatuation with the sci-fi…
11
Almost Friends (2017)
★ 6.3/10Also drama and comedy
A man in his mid-20s, still living at home with his mother and stepfather, puts all his eggs in one basket: the girl who works at his local coffee shop. The problem is, she has a serious boyfriend. As they become…
12
On Becoming a Guinea Fowl (2024)
★ 7.5/10Also comedy and drama
On an empty road in the middle of the night, Shula stumbles across the body of her uncle. As funeral proceedings begin around them, she and her cousins bring to light the buried secrets of their middle-class Zambian…
13
Happiness (1998)
★ 7.4/10Also comedy and drama
The lives of several individuals intertwine as they go about their lives in their own unique ways, engaging in acts which society as a whole might find disturbing in a desperate search for human connection.
14
Tyler Perry's Madea on the Run - The Play (2017)
★ 7.5/10Also comedy and drama
In trouble with the local authorities, Mabel Simmons, notoriously known as Madea, is on the run from the law. With no place to turn, she moves in with her friend Bam who is recovering from surgery. Unbeknownst to Bam…
15
The Professor (2019)
★ 6.8/10Also comedy and drama
A world-weary college professor is given a life-changing diagnosis and decides to throw all pretense and conventions to the wind and live his life as boldly and freely as possible with a biting sense of humor, a…
16
The Hollars (2016)
★ 6.3/10Also drama and comedy
Aspiring New York City artist John Hollar returns to his Middle America hometown on the eve of his mother’s brain surgery. Joined by his girlfriend Rebecca, eight months pregnant with their first child, John is forced…
17
My Dead Friend Zoe (2024)
★ 6.3/10Also comedy and drama
Merit, a U.S. Army veteran suffering from PTSD, is repeatedly tortured by visions of her deceased friend and company buddy Zoe. After her Afghanistan service in 2016, she attends group therapy until Dale, her…
18
Landline (2017)
★ 6.2/10Also comedy and drama
A teenager living with her sister and parents in Manhattan during the 1990s discovers that her father is having an affair.
19
I Love My Dad (2022)
★ 5.9/10Also comedy
A hopelessly estranged father catfishes his son in an attempt to reconnect.
20
If I Had Legs I'd Kick You (2025)
★ 6.3/10Also drama
With her life crashing down around her, Linda attempts to navigate her child's mysterious illness, her absent husband, a missing person, and an increasingly hostile relationship with her therapist.