Movies Like Patient Zero

If you liked Patient Zero (2011), a drama and thriller movie directed by Jacob Chase, here are 20 movies with a similar feel, based on TMDB's recommendations. Each one links to its cast, trailer and where it's streaming.

1
The House on Carroll Street (1988)
★ 5.9/10Also drama and thriller
A reporter, fired after refusing to give names to a 1951 House Un-American Activities Committee, takes a part-time job as companion to an old lady. While working she overhears a noisy argument in the neighboring house…
2
Light It Up (1999)
★ 6.6/10Also drama and thriller
On a winter day in a southside Queens high school, events collide and six students are suddenly in an armed standoff with the NYPD. At the school, classrooms freeze, teachers come and go, resources are scant.
3
SAS: Red Notice (2021)
★ 5.8/10Also drama and thriller
An off-duty SAS soldier, Tom Buckingham, must thwart a terror attack on a train running through the Channel Tunnel. As the action escalates on the train, events transpire in the corridors of power that may make the…
4
The Truth About Emanuel (2013)
★ 6/10Also drama and thriller
A troubled young woman becomes obsessed with her mysterious new neighbor, who bears a striking resemblance to the girl's dead mother.
5
The Hummingbird Project (2019)
★ 6.2/10Also thriller and drama
A pair of high-frequency traders go up against their old boss in an effort to make millions in a fiber-optic cable deal.
6
Chatroom (2010)
★ 5.8/10Also drama and thriller
When strangers Jim, Eva, Emily and Mo meet William online in his new 'Chelsea Teens!' chatroom, they're completely seduced by his fast-talking, charismatic character. But beneath the surface lies a much darker truth…
7
Run (1991)
★ 6/10Also thriller and drama
When a law student accidentally kills the son of a mob boss in a fight, he finds himself relentlessly pursued by the mob and the police.
8
6 Below: Miracle on the Mountain (2017)
★ 5.8/10Also thriller and drama
An adrenaline seeking snowboarder gets lost in a massive winter storm in the back country of the High Sierras where he is pushed to the limits of human endurance and forced to battle his own personal demons as he…
9
Tyler Perry's Duplicity (2025)
★ 6.6/10Also thriller and drama
High-powered attorney Marley faces her most personal case yet when she is tasked with uncovering the truth behind the murder of her best friend Fela’s husband. With the help of her boyfriend – a former cop turned…
10
The Good Neighbor (2022)
★ 6.6/10Also thriller and drama
A nightmarish evening unfolds for neighbors David and Robert when they accidentally hit a woman on her bike and flee the scene. While David is increasingly plagued by feelings of guilt, Robert shows no remorse and…
11
A Dry White Season (1989)
★ 6.7/10Also drama and thriller
During the 1976 Soweto uprising, a white school teacher's life and values are threatened when he asks questions about the death of a young black boy who died in police custody.
12
The Good Doctor (2011)
★ 6.2/10Also drama and thriller
Dr. Martin Blake, who has spent his life looking for respect, meets an 18-year-old patient named Diane, suffering from a kidney infection, and gets a much-needed boost of self-esteem. However, when her health starts…
13
Little Boy Blue (1998)
★ 6/10Also drama and thriller
Living in rural Texas is a dysfunctional family: an abusive dad, a Vietnam vet with a war wound that's left him impotent; a compliant wife and a son of about 20, two small sons who look a lot like their brother. The…
14
Awake (2007)
★ 6.6/10Also thriller
While undergoing heart surgery, a man experiences a phenomenon called ‘anesthetic awareness’, which leaves him awake but paralyzed throughout the operation. As various obstacles present themselves, his wife must make…
15
Hungry Hearts (2015)
★ 6.5/10Also drama
The relationship of a couple who meet by chance in New York City is put to the test when they encounter a life or death circumstance.
16
Guilty by Suspicion (1991)
★ 6.5/10Also drama and thriller
Owing to his alleged involvement with communist parties, film director David Merrill is forbidden from working in Hollywood. He decides to fight for his rights and faces numerous challenges.
17
The Killer (2024)
★ 6.3/10Also thriller
Zee is a feared contract killer known as "the Queen of the Dead," but when she refuses to murder a young blind woman, she finds herself hunted both by criminal colleagues and a determined police detective.
18
Bad Girl (2016)
★ 6/10Also thriller and drama
Bad girl Amy is given one last chance by her adoptive parents, who think her friendship with local girl Chloe is a step in the right direction. But when Amy discovers that Chloe harbors a dark secret, she finds herself…
19
The Operative (2019)
★ 5.8/10Also drama and thriller
A young Western woman is recruited by the Mossad to go undercover in Tehran where she becomes entangled in a complex triangle with her handler and her subject.
20
The Wasp (2024)
★ 6.3/10Also thriller and drama
Heather bumps into Carla, having not spoken to her in years, and presents her with a very unexpected proposition that could change both of their lives forever.