Movies Like Protocolo 48: El experimento final

If you liked Protocolo 48: El experimento final (2012), a comedy and science fiction movie directed by Carlos De La Fuente, here are 20 movies with a similar feel, based on TMDB's recommendations. Each one links to its cast, trailer and where it's streaming.

1
Infestation (2009)
★ 5.8/10Also comedy and horror
After being stung by a giant insect, Cooper learns that these bugs are attacking the whole city. He joins forces with the survivors, in order to find a way to counter-attack.
2
Relax, I'm from the Future (2023)
★ 5.9/10Also comedy and science fiction
Casper is a time traveller who arrives in the 2020s in an attempt to prevent a major future catastrophe. He meets Holly, a queer black woman he befriends and draws into his plan by giving her his knowledge of the…
3
La Leyenda de los Chaneques (2023)
★ 8.4/10Also comedy and horror
Five years after giving up his powers and separating from his friends, Leo San Juan has started a new life trying to focus on his family and their bakery, staying away from danger and adventures. However, Leo knows…
4
Afterburn (2025)
★ 6.2/10Also science fiction and comedy
Set against the backdrop of a postapocalyptic Earth whose Eastern Hemisphere was destroyed by a massive solar flare, leaving what life remains mutated from radiation and fallout. The story revolves around a group of…
5
Freaked (1993)
★ 6.2/10Also comedy and science fiction
A vain actor, his best friend, and an activist end up at a mutant freak farm run by a weirdo scientist.
6
Freaks of Nature (2015)
★ 6.1/10Also science fiction and comedy
In the town of Dillford, humans, vampires and zombies were all living in peace - until the alien apocalypse arrived. Now three teenagers-one human, one vampire, and one zombie-have to team up to figure out how to get…
7
Zygote (2017)
★ 7/10Also horror and science fiction
The two remaining crew members of a mining operation in the Arctic Circle fight to survive against an alien creature.
8
Real Men (1987)
★ 6/10Also comedy and science fiction
A womanizing CIA agent and an insecure insurance agent are paired together to make sure a deal goes through with aliens for the future of mankind.
9
Asylum: Twisted Horror and Fantasy Tales (2020)
★ 5.9/10Also comedy and horror
Brandon prepares to give his last stand-up comedy show. As his stories and jokes pass, the public begins to cheer up. But at that precise moment Brandon will realize that these stories have a strong relationship with…
10
Ick (2025)
★ 6/10Also horror and science fiction
Science teacher Hank’s life changes when he reconnects with his first love and suspects that a new student may be his daughter—all while facing an alien threat in their town.
11
Resident Evil (2002)
★ 6.7/10Also horror and science fiction
When a virus leaks from a top-secret facility, turning all resident researchers into ravenous zombies and their lab animals into mutated hounds from hell, the government sends in an elite military task force to contain…
12
Extinction (2015)
★ 6.4/10Also horror and science fiction
And suddenly, overnight, the world came to a halt. Two men, two survivors, one kid, and hatred that separates them. A place forgotten by everyone, including the creatures that inhabit the Earth... until now.
13
Return to... Return to Nuke 'Em High aka Vol. 2 (2017)
★ 6.4/10Also comedy and horror
Following the events of Volume 1, the mutated glee club continue their violent rampage in Tromaville. Chrissy and Lauren, two innocent lesbian lovers, must fight not only the Cretins, mutants, and monsters but also the…
14
Sleeper (1973)
★ 6.8/10Also comedy and science fiction
Miles Monroe, a clarinet-playing health food store proprietor, is revived out of cryostasis 200 years into a future world in order to help rebels fight an oppressive government regime.
15
Tremors: Shrieker Island (2020)
★ 6.1/10Also comedy and horror
When a group of hunters genetically modify Graboid eggs, they face an all-out war against the larger, terrifyingly intelligent creatures, and swiftly multiplying Shriekers!
16
The Bed Sitting Room (1969)
★ 5.9/10Also comedy and science fiction
In the hazy aftermath of World War III, the fallout from a 'nuclear misunderstanding' is producing strange mutations amongst the survivors, and the noble Lord Fortnum finds himself transforming into a bed sitting room.
17
Power Rangers Samurai: Clash of the Red Rangers - The Movie (2011)
★ 7.4/10Also comedy and science fiction
The Samurai Rangers team up with the mysterious RPM Ranger Red to fight off Master Xandred's Mooger army and a robotic supervillain from the RPM Ranger's dimension. But when both Red Rangers get struck with hypnobolts…
18
Snatchers (2019)
★ 6.5/10Also science fiction and horror
After status-obsessed teen Sara has sex for the first time, she wakes up the next day nine months pregnant-with an alien.
19
Monster Hunters (2020)
★ 6.2/10Also science fiction and horror
When an alien prison ship crash lands and unleashes creature after creature in the California desert, they make quick work of the army that tries to stop them. Now, the only hope of stopping the aliens rests with a…
20
Cold Storage (2026)
★ 6.7/10Also horror and science fiction
When a mutating, highly contagious fungus escapes a sealed facility, two employees – joined by a grizzled bioterror operative – must survive the wildest night shift ever to save humanity from extinction.