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Movies Like The Man with Two Brains

If you liked The Man with Two Brains (1983), a comedy and science fiction movie directed by Carl Reiner, here are 20 movies with a similar feel, based on TMDB's recommendations. Each one links to its cast, trailer and where it's streaming.

  1. 1Meet Cute

    Meet Cute (2022)

    ★ 5.8/10Also comedy and romance

    A wildly inventive deconstruction of the romantic comedy built around the question: What would you do if you could travel to your loved ones’ past, heal their traumas, fix their problems, and change them into the…

  2. 2Creator

    Creator (1985)

    ★ 6.2/10Also comedy and romance

    With the help of student assistant Boris and stolen university equipment, Dr. Harry Wolper plans to clone his dead wife. But then he meets Meli, an egg donor for his experiment, and they fall in love. Faced with…

  3. 3Real Men

    Real Men (1987)

    ★ 6/10Also comedy and science fiction

    A womanizing CIA agent and an insecure insurance agent are paired together to make sure a deal goes through with aliens for the future of mankind.

  4. 4Relax, I'm from the Future

    Relax, I'm from the Future (2023)

    ★ 5.9/10Also comedy and science fiction

    Casper is a time traveller who arrives in the 2020s in an attempt to prevent a major future catastrophe. He meets Holly, a queer black woman he befriends and draws into his plan by giving her his knowledge of the…

  5. 5Vanilla Sky

    Vanilla Sky (2001)

    ★ 6.8/10Also romance and science fiction

    David Aames has it all: wealth, good looks and gorgeous women on his arm. But just as he begins falling for the warmhearted Sofia, his face is horribly disfigured in a car accident. That's just the beginning of his…

  6. 6It's What's Inside

    It's What's Inside (2024)

    ★ 6.5/10Also comedy and science fiction

    A pre-wedding reunion descends into a psychological nightmare for a group of college friends when a surprise guest arrives with a mysterious suitcase.

  7. 7The Mating Habits of the Earthbound Human

    The Mating Habits of the Earthbound Human (1999)

    ★ 6/10Also comedy and romance

    David Hyde Pierce, playing an alien (credited as infinity-cubed in the opening credits), narrates a courtship in a late-20th century American city as an extraterrestrial nature documentary. The relationship "footage"…

  8. 8The Invention of Lying

    The Invention of Lying (2009)

    ★ 6.2/10Also comedy and romance

    Set in a world where the concept of lying doesn't exist, a loser changes his lot when he invents lying and uses it to get ahead.

  9. 9Palm Springs

    Palm Springs (2020)

    ★ 7.3/10Also comedy and romance

    When carefree Nyles and reluctant maid of honor Sarah have a chance encounter at a Palm Springs wedding, things get complicated when they find themselves unable to escape the venue, themselves, or each other.

  10. 10Idiocracy

    Idiocracy (2006)

    ★ 6.4/10Also comedy and science fiction

    To test its top-secret Human Hibernation Project, the Pentagon picks the most average European-Americans it can find - an Army private and a prostitute - and sends them to the year 2505 after a series of freak events…

  11. 11Focus

    Focus (2015)

    ★ 6.9/10Also romance and comedy

    Nicky, an accomplished con artist, gets romantically involved with his disciple Jess but later ends their relationship. Years later, she returns as a femme fatale to spoil his plans.

  12. 12Senseless

    Senseless (1998)

    ★ 6.2/10Also comedy and romance

    A student gets his senses enhanced by an experimental drug. But abuse is not an option.

  13. 13I Want You Back

    I Want You Back (2022)

    ★ 6.3/10Also comedy and romance

    Peter and Emma thought they were on the precipice of life’s biggest moments – marriage, kids, and houses in the suburbs – until their respective partners dumped them. Horrified to learn that the loves of their lives…

  14. 14Afterburn

    Afterburn (2025)

    ★ 6.2/10Also science fiction and comedy

    Set against the backdrop of a postapocalyptic Earth whose Eastern Hemisphere was destroyed by a massive solar flare, leaving what life remains mutated from radiation and fallout. The story revolves around a group of…

  15. 15Poor Things

    Poor Things (2023)

    ★ 7.6/10Also science fiction and romance

    Brought back to life by an unorthodox scientist, a young woman runs off with a lawyer on a whirlwind adventure across the continents. Free from the prejudices of her times, she grows steadfast in her purpose to stand…

  16. 16About Fate

    About Fate (2022)

    ★ 7.5/10Also romance and comedy

    Two strangers believe in love but never seem to be able to find its true meaning. In a wild twist of events, fate puts each in the other's path on one stormy New Year's Eve.

  17. 17I Married a Strange Person!

    I Married a Strange Person! (1998)

    ★ 7.2/10Also comedy and science fiction

    On their wedding night, Grant begins experiencing strange, supernatural powers and his bride Keri can't cope. Whenever Grant thinks of something, it becomes reality, yet he doesn't know where this magic came from…

  18. 18Starting Over

    Starting Over (1979)

    ★ 6.4/10Also comedy and romance

    After divorcing his ambitious singer wife, a middle-aged man begins a new relationship with a teacher.

  19. 19Happy Accidents

    Happy Accidents (2000)

    ★ 6.8/10Also comedy and romance

    A comedy that pays tribute to the science fiction genre -- specifically, the sub-genre of time travel. But here the alternate reality is contemporary New York City where past and future experiences of trust, commitment…

  20. 20Playing It Cool

    Playing It Cool (2014)

    ★ 5.9/10Also comedy and romance

    A young man meets and instantly falls in love with an engaged woman.

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