Movies Like Microdosing

If you liked Microdosing (2023), a science fiction and comedy movie directed by Patrick Adam Peña, here are 20 movies with a similar feel, based on TMDB's recommendations. Each one links to its cast, trailer and where it's streaming.

1
Freaked (1993)
★ 6.2/10Also comedy and science fiction
A vain actor, his best friend, and an activist end up at a mutant freak farm run by a weirdo scientist.
2
Cranston Academy: Monster Zone (2020)
★ 6/10Also animation and science fiction
An intelligent 15-year-old high school student is unexpectedly transferred to a boarding school where he opens a portal of monsters from another dimension.
3
Amazon Women on the Moon (1987)
★ 5.9/10Also comedy and science fiction
Centered on a television station which features a 1950s-style sci-fi movie interspersed with a series of wild commercials, wacky shorts and weird specials, this lampoon of contemporary life and pop culture skewers some…
4
Afterburn (2025)
★ 6.2/10Also science fiction and comedy
Set against the backdrop of a postapocalyptic Earth whose Eastern Hemisphere was destroyed by a massive solar flare, leaving what life remains mutated from radiation and fallout. The story revolves around a group of…
5
Altered States (1980)
★ 6.7/10Also horror and science fiction
A research scientist explores the boundaries and frontiers of human consciousness. Using sensory deprivation and hallucinogenic mixtures from Native American shamans, he explores these altered states of cognizance and…
6
Stewie Griffin: The Untold Story (2005)
★ 6.9/10Also animation and comedy
The maniacal baby of the Griffin family, Stewie, meets his future self. In doing this he discovers that his future image is not what he has anticipated because of a near death experience.
7
Mutant Pumpkins from Outer Space (2009)
★ 6.1/10Also animation and comedy
Susan Murphy (a.k.a. Ginormica) and the Monsters are now working with the US government as special ops. So when an alien presence is detected in Susan's hometown of Modesto, California -- right before Halloween -- the…
8
Real Men (1987)
★ 6/10Also comedy and science fiction
A womanizing CIA agent and an insecure insurance agent are paired together to make sure a deal goes through with aliens for the future of mankind.
9
Psycho Goreman (2020)
★ 6/10Also science fiction and comedy
Siblings Mimi and Luke unwittingly resurrect an ancient alien overlord. Using a magical amulet, they force the monster to obey their childish whims, and accidentally attract a rogues’ gallery of intergalactic assassins…
10
Society (1990)
★ 6.7/10Also comedy and horror
Bill Whitney is worried that he is different to his sister and parents. They mix with other upper-class people while Bill is more down to earth. Even his girlfriend seems a bit odd. All is revealed when Bill returns…
11
The Bed Sitting Room (1969)
★ 5.9/10Also comedy and science fiction
In the hazy aftermath of World War III, the fallout from a 'nuclear misunderstanding' is producing strange mutations amongst the survivors, and the noble Lord Fortnum finds himself transforming into a bed sitting room.
12
The Hidden (1987)
★ 6.9/10Also science fiction and horror
When average, law-abiding citizens suddenly turn to a life of hedonistic behavior and violent crime, Detective Tom Beck is tasked with helping young FBI agent Lloyd Gallagher determine the cause.
13
Dr. Caligari (1989)
★ 5.8/10Also horror and science fiction
Mrs. Van Houten has shown signs of losing touch with reality, and her husband discusses possible treatment with Dr. Caligari, who says Mrs. Van Houten has a disease of the libido.
14
Planet 51 (2009)
★ 5.9/10Also animation and comedy
When Earth astronaut Capt. Chuck Baker arrives on Planet 51 -- a world reminiscent of American suburbia circa 1950 -- he tries to avoid capture, recover his spaceship and make it home safely, all with the help of an…
15
The Day the Earth Blew Up: A Looney Tunes Movie (2024)
★ 7.5/10Also comedy and animation
Porky and Daffy, the classic animated odd couple, turn into unlikely heroes when their antics at the local bubble gum factory uncover a secret alien mind control plot. Against all odds, the two are determined to save…
16
Yellow Mirror (2026)
★ 8.1/10Also animation and comedy
A defective lamp reveals a heartbreaking truth about what Homer believes is reality, and an AI-powered tablet befriends and controls Maggie. The Simpsons struggle to find the light through two dark tales of the curious…
17
Asylum: Twisted Horror and Fantasy Tales (2020)
★ 5.9/10Also comedy and horror
Brandon prepares to give his last stand-up comedy show. As his stories and jokes pass, the public begins to cheer up. But at that precise moment Brandon will realize that these stories have a strong relationship with…
18
Ick (2025)
★ 6/10Also horror and science fiction
Science teacher Hank’s life changes when he reconnects with his first love and suspects that a new student may be his daughter—all while facing an alien threat in their town.
19
Eraserhead (1977)
★ 7.3/10Also horror and science fiction
First-time father Henry Spencer tries to survive his industrial environment, his angry girlfriend, and the unbearable screams of his newly born mutant child.
20
Infestation (2009)
★ 5.8/10Also comedy and horror
After being stung by a giant insect, Cooper learns that these bugs are attacking the whole city. He joins forces with the survivors, in order to find a way to counter-attack.