Movies Like Destination: Infestation

If you liked Destination: Infestation (2007), a action and science fiction movie directed by George Mendeluk, here are 20 movies with a similar feel, based on TMDB's recommendations. Each one links to its cast, trailer and where it's streaming.

1
Shadow in the Cloud (2021)
★ 5.8/10Also horror and action
A WWII pilot traveling with top secret documents on a B-17 Flying Fortress encounters an evil presence on board the flight.
2
Black Box (2026)
★ 5.9/10Also horror and thriller
Vero Airlines Flight 298 from New Orleans to Seattle becomes the center of a chilling supernatural mystery.
3
The Bay (2012)
★ 5.8/10Also horror and science fiction
Chaos breaks out in a small Maryland town after an ecological disaster occurs.
4
The Crazies (2010)
★ 6.3/10Also horror and action
Four friends find themselves trapped in their small hometown after they discover their friends and neighbors going quickly and horrifically insane.
5
The Signal (2007)
★ 5.9/10Also horror and science fiction
A horror film told in three parts, from three perspectives, in which a mysterious transmission that turns people into killers invades every cell phone, radio, and television.
6
Extinction (2015)
★ 6.4/10Also horror and science fiction
And suddenly, overnight, the world came to a halt. Two men, two survivors, one kid, and hatred that separates them. A place forgotten by everyone, including the creatures that inhabit the Earth... until now.
7
Containment (2015)
★ 5.9/10Also thriller and horror
Neighbors in a block wake one morning to find they have been sealed inside their apartments. Can they work together to find out why? Or will they destroy each other in their fight to escape?
8
Hidden (2015)
★ 7/10Also thriller and horror
A family takes refuge in a fallout shelter to avoid a dangerous outbreak.
9
Megaboa (2021)
★ 6.3/10Also action and horror
On a trip to Colombia, a group of college students encounter a fifty-foot boa constrictor, hungry for blood.
10
Crawlers (2020)
★ 5.9/10Also horror and science fiction
On Saint Patrick's day—a night of wild parties and drunken revelry—three unlikely friends band together to save a college town from a vicious horde of body-snatching aliens.
11
Desert Dawn (2025)
★ 6.3/10Also action and thriller
A newly appointed small-town sheriff and his begrudging deputy get tangled up in a web of lies and corruption involving shady businessmen and the cartel while investigating the murder of a mysterious woman.
12
The Relic (1997)
★ 6.2/10Also horror and thriller
A homicide detective teams up with an evolutionary biologist to hunt a giant creature that is killing people in a Chicago museum.
13
Splinter (2008)
★ 6.2/10Also horror and thriller
When their plans for a nature trip go awry, Polly and boyfriend Seth decide to check into a motel. On their way, they're carjacked and kidnapped by low-rent crooks Dennis and Lacey, who take the victims and their SUV…
14
Mimic (1997)
★ 6.1/10Also horror and science fiction
A disease carried by common cockroaches is killing Manhattan children. In an effort to stop the epidemic an entomologist, Susan Tyler, creates a mutant breed of insect that secretes a fluid to kill the roaches. This…
15
Goodnight Mommy (2022)
★ 6.3/10Also horror and thriller
When twin brothers arrive home to find their mother’s demeanor altered and face covered in surgical bandages, they begin to suspect the woman beneath the gauze might not be their mother.
16
Mad God (2021)
★ 6.8/10Also horror and science fiction
A silent figure known as The Assassin travels through a nightmare underworld of tortured souls, ruined cities and wretched monstrosities forged from the primordial horrors of the unconscious mind of Phil Tippett, the…
17
Don't Let Go (2019)
★ 6.9/10Also horror and science fiction
A detective suffering from a personal loss receives a call from his recently deceased niece. Being able to communicate across time, the two work together to try and stop the crime before it occurs.
18
V/H/S/Beyond (2024)
★ 6.6/10Also horror and science fiction
The infinite playground of forbidden worlds and dangerous lifeforms offered by the sci-fi horror genre will lead to the biggest, maddest, bloodiest V/H/S ever.
19
Frankenstein Unbound (1990)
★ 5.9/10Also horror and science fiction
The ultimate weapon, claimed to be safe for mankind, produces global side-effects including time slides and disappearances. The scientist behind the project and his car are zapped from the year 2031 to 1817 in…
20
Breaking In (2018)
★ 6/10Also action and thriller
Shaun Russell takes her son and daughter on a weekend getaway to her late father's secluded, high-tech vacation home in the countryside. The family soon gets an unwelcome surprise when four men break into the house to…